The PHNCI Innovation Learning Community grantees spent eighteen months hard at work implementing innovations in their communities. From this community, we have been able to learn what makes an innovation work and be replicable, including leadership buy-in, cross-sector partnerships, and community engagement. In addition to learning about innovation broadly from these grantees, we also want to highlight each grantee’s individual work, including success, challenges, and lessons learned for others who may be interested in replicating their work. The case studies below, produced by NORC at the University of Chicago, are great resources for any agency looking to bring public health innovation to serve the needs of its community.